Rod photoreceptor degeneration causes deterioration in the morphology and physiology of cone photoreceptors along with changes in retinal circuits.These changes could diminish visual signaling at cone-mediated light levels, thereby limiting the efficacy of treatments such as gene therapy for rescuing normal, cone-mediated vision.However, the impact
The Ability of AhR Ligands to Attenuate Delayed Type Hypersensitivity Reaction Is Associated With Alterations in the Gut Microbiota
Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that regulates T cell function.The aim of this study was to investigate the effects of AhR ligands, 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), and 6-Formylindolo[3,2-b]carbazole (FICZ), on gut-associated microbiota and T cell responses during delayed-type hypersensitivity (
Augmented interferon regulatory factor 7 axis in whole tumor cell vaccines prevents tumor recurrence by inducing interferon gamma-secreting B cells
Among cancer immunotherapy, which has received great attention in recent years, cancer vaccines can potentially prevent recurrent tumors by using the exquisite power and specificity of the immune system.Specifically, whole tumor cell vaccines (WTCVs) based on surgically resected tumors have been considered to elicit robust anti-tumor immune respons
Manufacture and Characterization of Alginate-CMC-Dextran Hybrid Double Layer Superabsorbent Scaffolds
This study focused on the manufacturing of functional superabsorbent sponges using natural polymers.An alginate/CMC-embedded dextran hybrid dual-layer formulation was prepared using the freeze-drying method.The physical properties of the formulation were characterized using a field emission scanning electron microscope and a universal testing machi